Optic Disc (OD) localization is an important pre-processing step that significantly simplifies subsequent segmentation of the OD and other retinal structures. Current OD localization techniques suffer from impractically-high computation times (few minutes per image). In this work, we present a fast technique that requires less than a second to localize the OD. The technique is based upon obtaining two projections of certain image features that encode the x- and y- coordinates of the OD. The resulting 1-D projections are then searched to determine the location of the OD. This avoids searching

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Purpose. To develop a method for identifying abnormal myocardial function based on studying the normalized wall motion pattern during the cardiac cycle. Methods. The temporal pattern of the normalized myocardial wall thickness is used as a feature vector to assess the cardiac wall motion abnormality. Principal component analysis is used to reduce the feature dimensionality and the maximum likelihood method is used to differentiate between normal and abnormal features. The proposed method was applied on a dataset of 27 cases from normal subjects and patients. Results. The developed method

Global overpopulation, industrial expansion, and urbanization have generated massive amounts of wastes. This is considered as a significant worldwide challenge that requires an urgent solution. Additionally, remarkable advances in the field of biomedicine have impacted the entire spectrum of healthcare and medicine. This has paved the way for further refining of the outcomes of biomedical strategies toward early detection and treatment of different diseases. Various nanomaterials (NMs) have been dedicated to different biomedical applications including drug delivery, vaccinations, imaging

Text classification has been one of the most common natural language processing (NLP) objectives in recent years. Compared to other languages, this mission with Arabic is relatively restricted and in its early stages, and this combination in the medical application area is rare. This paper builds an Arabic health care assistant, specifically a pediatrician that supports Arabic dialects, especially Egyptian accents. The proposed application is a chatbot based on Artificial Intelligence (AI) models after experimenting with Two Bidirectional Encoder Representations from Transformers (BERT) models

Background: Taurine-upregulated gene 1 (TUG1) is one of the long noncoding RNAs (lncRNAs) that plays a role in melanogenesis. MicroRNA-377 (miRNA-377) is a conserved noncoding RNA that regulates angiogenesis and promotes oxidative stress. Peroxisome proliferator-activated receptors (PPARs) are components of the nuclear hormone receptor superfamily. PPAR-γ activators stimulate melanogenesis. Interleukin (IL)-17 has been implicated in the pathogenesis of several immunological diseases. This work aimed at detecting the expression levels of lncRNA TUG1, miRNA-377, PPAR-γ, and IL-17 among vitiligo

Background: Data have been accumulating in the past few years that identify vitiligo as a disorder with systemic implications. Results and methods: In this hospital-based, cross-sectional, case–control study, 50 patients with non-segmental vitiligo and 50 age- and sex-matched controls underwent analysis of serum lipid profile, oxidative stress biomarkers and carotid duplex. Hydrogen peroxide (H2O2) and malondialdehyde (MDA) were significantly higher in patients than controls (p-value <.001, <.001, respectively); on the other hand, total antioxidant capacity (TAC) was significantly lower in

Introduction: The hyper-catabolic state is a devastating pathophysiological response to severe injury, infection or burns. Nandrolone decanoate (ND) is a potent anabolic steroid have many clinical indications, but not investigated in burn injuries yet. Patients and methods: A prospective randomized control study included 40 burned patients who were treated in Burn unit from burn injuries ranged from 20 to 40%. Both groups are objectively assessed, clinically and laboratory during treatment period till full recovery from burns’ injury. Recall assessment of the drug safety after many years is

Cellular respiration is an important process performed by mitochondria. Nad complex is the major complex involved in this process and one of the main subunits in this complex is the nad7 (nad dehydrogenase subunit 7). In Hordeum vulgare subsp. spontaneum, four nad7 cDNAs are described at 500 mM salinity, 0 h, or control (GenBank accession no. MW433884), after 2 h (GenBank accession no. MW433885), after 12 h (GenBank accession no. MW433886) and after 24 h (GenBank accession no. MW433887). Twenty six RNA editing sites were revealed in positions: C44, C45, C77, C83, C99, C137, C224, C244, C251

Introduction: Cancer is one of the most difficult challenges faced by humanity due to its many associated issues, such as inability to prevent diseases, treatment safety, and high mortality rate. In cancer, a variety of cellular signaling is activated to ensure malignancy transformation, angiogenesis and metastasis. The most efficient signaling pathway in cancer is mitogen-activated protein kinase (MAPK), which controls malignancy and regulates apoptosis. Methods: Four different flavonoid glycosides have been isolated from Pulicaria jaubertii using the phytochemical characterization of hydro