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Streaming support for data intensive cloud-based sequence analysis
Cloud computing provides a promising solution to the genomics data deluge problem resulting from the advent of next-generation sequencing (NGS) technology. Based on the concepts of "resources-on-demand" and "pay-as-you-go", scientists with no or limited infrastructure can have access to scalable and cost-effective computational resources. However, the large size of NGS data causes a significant data transfer latency from the client's site to the cloud, which presents a bottleneck for using cloud computing services. In this paper, we provide a streaming-based scheme to overcome this problem
Named entity recognition of persons' names in Arabic tweets
The rise in Arabic usage within various socialmedia platforms, and notably in Twitter, has led to a growing interest in building ArabicNatural Language Processing (NLP) applications capable of dealing with informal colloquialArabic, as it is the most commonly used form of Arabic in social media. The uniquecharacteristics of the Arabic language make the extraction of Arabic named entities achallenging task, to which, the nature of tweets adds new dimensions. The majority ofprevious research done on Arabic NER focused on extracting entities from the formallanguage, namely Modern Standard Arabic
Survey and taxonomy of information-centric vehicular networking security attacks
Information Centric Networks (ICNs) overcome the current IP-based networks weakness and aim to ensure efficient data distribution. The Main ICN features are location-independent naming, in-network caching, name-based routing, built-in security, and high mobility. ICN vehicular networks stratify the ICN architecture on the Vehicular Ad hoc Networks (VANETs) to reinforce a massive amount of data transmission and handle the critical time interests inside the vehicular networks while taking into consideration the vehicles’ high mobility. Original Equipment Manufacturers (OEMs) gather the real-time
Myocardial segmentation using contour-constrained optical flow tracking
Despite the important role of object tracking using the Optical Flow (OF) in computer graphics applications, it has a limited role in segmenting speckle-free medical images such as magnetic resonance images of the heart. In this work, we propose a novel solution of the OF equation that allows incorporating additional constraints of the shape of the segmented object. We formulate a cost function that include the OF constraint in addition to myocardial contour properties such as smoothness and elasticity. The method is totally different from the common naïve combination of OF estimation within
Myocardium segmentation in strain-encoded (SENC) magnetic resonance images using graph-cuts
Evaluation of cardiac functions using Strain Encoded (SENC) magnetic resonance (MR) imaging is a powerful tool for imaging the deformation of left and right ventricles. However, automated analysis of SENC images is hindered due to the low signal-to-noise ratio SENC images. In this work, the authors propose a method to segment the left and right ventricles myocardium simultaneously in SENC-MR short-axis images. In addition, myocardium seed points are automatically selected using skeletonisation algorithm and used as hard constraints for the graph-cut optimization algorithm. The method is based
In silico design and experimental validation of sirnas targeting conserved regions of multiple hepatitis c virus genotypes
RNA interference (RNAi) is a post-transcriptional gene silencing mechanism that mediates the sequence-specific degradation of targeted RNA and thus provides a tremendous opportunity for development of oligonucleotide-based drugs. Here, we report on the design and validation of small interfering RNAs (siRNAs) targeting highly conserved regions of the hepatitis C virus (HCV) genome. To aim for therapeutic applications by optimizing the RNAi efficacy and reducing potential side effects, we considered different factors such as target RNA variations, thermodynamics and accessibility of the siRNA
New approach for data acquisition and image reconstruction in parallel magnetic resonance imaging
In this study, we propose a novel data acquisition and image reconstruction method for parallel magnetic resonance imaging (MRI). The proposed method improves the GRAPPA algorithm by simultaneously collecting data using the body coil in addition to localized surface coils. The body coil data is included in the GRAPPA reconstruction as an additional coil. The reconstructed body coil image shows greater uniformity over the field of view than the conventional sum-of-squares (SoS) reconstruction that is conventionally used with GRAPPA. The body coil image can also be used to correct for spatial
New feature splitting criteria for co-training using genetic algorithm optimization
Often in real world applications only a small number of labeled data is available while unlabeled data is abundant. Therefore, it is important to make use of unlabeled data. Co-training is a popular semi-supervised learning technique that uses a small set of labeled data and enough unlabeled data to create more accurate classification models. A key feature for successful co-training is to split the features among more than one view. In this paper we propose new splitting criteria based on the confidence of the views, the diversity of the views, and compare them to random and natural splits. We
Improved estimation of the cardiac global function using combined long and short axis MRI images of the heart
Background: Estimating the left ventricular (LV) volumes at the different cardiac phases is necessary for evaluating the cardiac global function. In cardiac magnetic resonance imaging, accurate estimation of the LV volumes requires the processing a relatively large number of parallel short-axis cross-sectional images of the LV (typically from 9 to 12). Nevertheless, it is inevitable sometimes to estimate the volume from a small number of cross-sectional images, which can lead to a significant reduction of the volume estimation accuracy. This usually encountered when a number of cross-sectional
Inherent fat cancellation in complementary spatial modulation of magnetization
An efficient fat suppression method is presented for MR tagging with complementary spatial modulation of magnetization (CSPAMM). In this method, the complementary modulation is applied to the water content of the tissues, while in-phase modulation is applied to the fat content. Therefore, during image reconstruction, the subtraction of the acquired images increases the tagging contrast of the water while cancels the tagging lines of the fat. Compared with the existing fat suppression techniques, the proposed method allows imaging with higher temporal resolution and shorter echo-time without
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