Fractional-Order Generalized Gene Regulation Model CCII-Based Practical Emulator

This paper presents a practical emulator of a generalised fractional-order model for gene regulation process, in an analog platform. The presented emulator is based on the second-generation current conveyor (CCII) and implemented using AD844 chips. The emulator realises a proposed generalised mathematical model for gene expression. The model sums up three different single models; the constitutive gene model, the induced gene expression under the effect of activators and repressors models. The generalised model is based on fractional-order differential equations where the concentration of the mRNA and the Protein expressed are the model variables. The study of model dynamics is detailed, and the experimental results are presented to confirm the accuracy between the practical emulator and the theoretical models. With the aid of fractional-order parameters, the proposed emulator helps test and analyse the gene regulation process. The management of drug doses and forecast of the exact timing to kill cancer cells is just an example of how to benefit from this emulator without practical animal or human tests. © 2020 IEEE.