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Natural products and long noncoding RNA signatures in gallbladder cancer: a review focuses on pathogenesis, diagnosis, and drug resistance

Gallbladder cancer (GBC) is an aggressive and lethal malignancy with a poor prognosis. Long noncoding RNAs (lncRNAs) and natural products have emerged as key orchestrators of cancer pathogenesis through widespread dysregulation across GBC transcriptomes. Functional studies have revealed that lncRNAs interact with oncoproteins and tumor suppressors to control proliferation, invasion, metastasis

Artificial Intelligence
Healthcare
Circuit Theory and Applications
Software and Communications
Mechanical Design

Facile sonochemically-assisted bioengineering of titanium dioxide nanoparticles and deciphering their potential in treating breast and lung cancers: biological, molecular, and computational-based investigations

Combining sonochemistry with phytochemistry is a modern trend in the biosynthesis of metallic nanoparticles (NPs), which contributes to the sustainability of chemical processes and minimizes hazardous effects. Herein, titanium dioxide (TiO2) NPs were bioengineered using a novel and facile ultrasound-assisted approach utilizing the greenly extracted essential oil of Ocimum basilicum. FTIR and UV

Artificial Intelligence
Energy and Water
Circuit Theory and Applications

Chronic tobacco smoking and neurocognitive impairments in adolescents and young adults: a systematic review and meta-analysis

There is a lack of robust research investigating the association between neurocognitive impairments and chronic tobacco smoking in adolescents/young adults. Therefore, a systematic review and meta-analysis were conducted to examine this association by pooling cross-sectional studies published from 1980 to 2023. The systematic review assessed the neurocognitive performances between chronic tobacco

Artificial Intelligence
Circuit Theory and Applications

Cold tolerance of woodland strawberry (Fragaria vesca) is linked to Cold Box Factor 4 and the dehydrin Xero2

Domesticated strawberry is susceptible to sudden frost episodes, limiting the productivity of this cash crop in regions where they are grown during early spring. In contrast, the ancestral woodland strawberry (Fragaria vesca) has successfully colonized many habitats of the Northern Hemisphere. Thus, this species seems to harbour genetic factors promoting cold tolerance. Screening a germplasm

Artificial Intelligence
Circuit Theory and Applications
Agriculture and Crops

Unravelling the Functional Role of GthGAPC2 in Cotton's Defense Against Verticillium dahliae through Proteome

Cotton (Gossypium spp.) is an economically important crop, but its productivity is often hindered by the soil-borne pathogen Verticillium dahliae. This study aimed to investigate the response of cotton roots to V. dahliae infection by analysing the proteome of Gossypium thurberi (resistant) and Gossypium raimondii (susceptible) at 0 h, 24 h, and 48 h post-infection. Through weighted protein

Artificial Intelligence
Healthcare
Circuit Theory and Applications
Software and Communications
Agriculture and Crops

In silico analysis of the structural and functional characterization of the phosphorus-starvation tolerance 1 (PSTOL1) gene

As an important macro element for all living cells, phosphorus is essential in agricultural production systems and is required in large quantities by elite varieties of crops to maintain yields. Approximately 70% of the worldwide cultivated land suffers from phosphorous deficiency, and it has recently been estimated that the worldwide phosphorous resources will be shattered by the end of this

Artificial Intelligence
Circuit Theory and Applications
Software and Communications
Agriculture and Crops

DiDBiT-TMT: A Novel Method to Quantify Changes in the Proteomic Landscape Induced by Neural Plasticity

Direct detection of biotinylated proteins (DiDBiT) is a proteomic method that can enrich and detect newly synthesized proteins (NSPs) labeled with bio-orthogonal amino acids with 20-fold improved detectability compared to conventional methods. However, DiDBiT has currently been used to compare only two conditions per experiment. Here, we present DiDBiT-TMT, a method that can be used to quantify

Artificial Intelligence
Healthcare
Circuit Theory and Applications
Software and Communications

Synergism between Saccharomyces cerevisiae probiotic and rosemary nano-emulsion: Effect on broiler chicken meat quality and shelf life

Although several studies have investigated the effect of either probiotic feed additives or postmortem meat treatment on the quality of obtained chicken meat, the impact of combined treatment with probiotic feed additives along with meat dipping in essential oil nano-emulsion on meat shelf-life is barely examined. There-fore, this study investigated the effect of combined treatment with

Artificial Intelligence
Healthcare
Circuit Theory and Applications
Software and Communications

Identification of Candidate Genes for Rice Nitrogen Use Efficiency by Genome-wide Association Analysis; [全基因组关联分析(GWAS)鉴定水稻氮素利用效率候选基因]

【Objective】 The exploration of germplasm and gene resources in rice for high nitrogen efficiency, along with the elucidation of their molecular mechanisms and genetic effects, represents a significant focus and goal within current research efforts on rice nitrogen use efficiency (NUE).【Method】 To identify the variant loci and candidate genes associated with rice NUE, we collected 190 Asian rice

Artificial Intelligence
Healthcare
Circuit Theory and Applications
Software and Communications

Genome-wide analysis and expression divergence of protein disulfide isomerase (PDI) gene family members in chickpea (Cicer arietinum) under salt stress

Chickpea (Cicer arietinum) is a grain crop that is an important source of protein, vitamins, carbohydrates and minerals. It is highly sensitive to salt stress, and salt damage to cellular homeostasis and protein folding affects production. Plants have several mechanisms to prevent cellular damages under abiotic stresses, such as proteins in the endoplasmic reticulum (protein isulfide somerases

Artificial Intelligence
Healthcare
Circuit Theory and Applications
Software and Communications
Agriculture and Crops